Kiuas writes: Researchers from the Technical University of Munich and the University of Helsinki have discovered a second receptor (called neuropilin-1) which is used by the SARS-CoV-2 virus to enter into human cells via the nasal cavity. The discovery is important as it helps explain the rapid spread of the virus, and also helps define a potential target for antirviral intervention... The study itself was published in the Science magazine on the 20th of October. More details announced by the University of Helsinki: "That SARS-CoV-2 uses the receptor ACE2 to infect our cells was known, but viruses often use multiple factors to maximize their infectious potential" says Dr. Giuseppe Balistreri, head of the research group Viral Cell Biology at the University of Helsinki involved in the study. "Unlike the main receptor ACE2, which is present in low levels, Neuropilin-1 is very abundant in the cells of the nasal cavity. This is a strategically important localization possibly contributing to the efficient infectivity of this new coronavirus, which has caused a major pandemic, spreading rapidly around the world", Balistreri explains... By specifically blocking neuropilin-1 with antibodies, the researchers were able to significantly reduce infection in laboratory cell cultures. "If you think of ACE2 as a door lock to enter the cell, then neuropilin-1 could be a factor that directs the virus to the door. ACE2 is expressed at very low levels in most cells. Thus, it is not easy for the virus to find doors to enter. Other factors such as neuropilin-1 might help the virus finding its door", says Balistreri... Balistreri cautiously concludes "it is currently too early to speculate whether blocking directly neuropilin could be a viable therapeutic approach, as this could lead to side effects. This will have to be looked at in future studies. Currently our laboratory is testing the effect of new molecules that we have specifically designed to interrupt the connection between the virus and neuropilin. Preliminary results are very promising and we hope to obtain validations in vivo in the near future."

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The New York Times reports: Cybersecurity officials watched with growing alarm in September as Russian state hackers started prowling around dozens of American state and local government computer systems just two months before the election. The act itself did not worry them so much — officials anticipated that the Russians who interfered in the 2016 election would be back — but the actor did. The group, known to researchers as "Dragonfly" or "Energetic Bear" for its hackings of the energy sector, was not involved in 2016 election hacking. But it has in the past five years breached the power grid, water treatment facilities and even nuclear power plants, including one in Kansas... September's intrusions marked the first time that researchers caught the group, a unit of Russia's Federal Security Service, or F.S.B., targeting states and counties. The timing of the attacks so close to the election and the potential for disruption set off concern inside private security firms, law enforcement and intelligence agencies... American officials described the hackings in an advisory on Thursday as "opportunistic," rather than a clear attack on election infrastructure, but conceded the group had targeted dozens of state and local systems and stolen data from at least two targets' servers. "They're broadly looking to scan for vulnerabilities and they're working opportunistically," said Christopher C. Krebs, the director of the Cybersecurity and Infrastructure Security Agency, which issued the warning along with the F.B.I. That hardly reassured researchers who have tracked Energetic Bear for years. "This appears to be preparatory, to ensure access when they decide they need it," said Adam Meyers, the head of threat intelligence at CrowdStrike, a security firm that has monitored the group... A disturbing screenshot in a 2018 Department of Homeland Security advisory showed the groups' hackers with their fingers on the switches of the computers that controlled the industrial systems at a power plant. The group has thus far stopped short of sabotage, but appears to be preparing for some future attack. The hackings so unnerved officials that starting in 2018, the United States Cyber Command, the arm of the Pentagon that conducts offensive cyberattacks, hit back with retaliatory strikes on the Russian grid.

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The Washington Post reports: App developers are defying Apple in record numbers, according to a new coalition of companies aimed at breaking the iPhone maker's tight grip over its mobile software and the way it governs the App Store. The Coalition for App Fairness, which launched last month and counts as members video-game giant Epic Games, dating company Match Group and music streaming service Spotify, says the original group of 13 companies has grown to 40, and it has received more than 400 requests to join. "The outpouring of interest we've received has exceeded our expectations," Sarah Maxwell, a spokeswoman for the coalition, said in an emailed statement. "As we bring on new members and hear their stories, it's evident that too many developers have been unable to make their voices heard." The soaring membership of the coalition represents a remarkable shift in thinking, as companies and individual developers take the risky step of speaking out in an effort to change the way Apple operates... Developers say they worried that complaining about Apple would hurt their ability to get apps and updates approved. The company's App Store Review Guidelines once contained a warning for developers who might consider protesting Apple's policies: "If your app is rejected, we have a Review Board that you can appeal to. If you run to the press and trash us, it never helps," the guidelines once stated, according to a securities filing... The Coalition for App Fairness aims to sway lawmakers to take action against Apple, either through new legislation or legal action. More freedom on iOS would lead to more innovation, app developers say.

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"It's finally happening: Twitch is taking action against copyrighted music — long a norm among streamers — in response to music industry pressure," reports Kotaku. But the Verge reports "there's some funny stuff going on here." First, Twitch is telling streamers that some of their content has been identified as violating copyright and that instead of letting streamers file counterclaims, it's deleting the content; second, the company is telling streamers it's giving them warnings, as opposed to outright copyright strikes... Weirdly Twitch decided to bulk delete infringing material instead of allowing streamers to archive their content or submit counterclaims. To me, that suggests that there are tons of infringements, and that Twitch needed to act very quickly and/or face a lawsuit it wouldn't be able to win over its adherence to the safe harbor provision of the DMCA. The email Twitch sent to their users "encourages them to delete additional content — up to and including using a new tool to unilaterally delete all previous clips," reports Kotaku. One business streamer complains that it's "insane" that Twitch basically informs them "that there is more content in violation despite having no identification system to find out what it is. Their solution to DMCA is for creators to delete their life's work. This is pure, gross negligence." Or, as esports consultant Rod "Slasher" Breslau puts it, "It is absolutely insane that record labels have put Twitch in a position to force streamers to delete their entire life's work, for some 10+ years of memories, and that Twitch has been incapable of preventing or aiding streamers for this situation. a total failure all around." Twitch's response? It is crucial that we protect the rights of songwriters, artists and other music industry partners. We continue to develop tools and resources to further educate our creators and empower them with more control over their content while partnering with industry-recognized vendors in the copyright space to help us achieve these goals.

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The Times of London reports: A gang of cyberexperts turned a former German military bunker into one of Europe's biggest hubs for the "dark web" and a superhighway for at least a quarter of a million offences, including drug trafficking and the falsification of identity papers, a court has been told. Four people from the Netherlands, three Germans and a Bulgarian are accused of creating a digital safe haven in which criminals could operate with impunity. Dutch News reports: Deals which were processed through the servers include drugs — with platforms such as Cannabis Road — which had millions of active users, the Telegraaf said on Tuesday. Other sites allowed people to order fake money and ID papers, and the bunker was also used to stage a bot attack on German telecom firm Deutsche Telekom, the paper said. The investigation into the bunker took years of observation and phone tapping, culiminating in a raid involving 650 police officers in September 2019. . Long-time Slashdot reader Qbertino writes: Prosecuters believe to have a case which is set to take 15 months until the end of 2021 simply due to the sheer mass of material they've gatherd to make a case. The defendants, which include adolescents at the time of crime, face up to 15 years in prison should they be convicted. As recently as this June, the cyberbunker was still being contacted by several phishing sites, as well as thousands of bots looking for their old command and control server.

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PeerTube (developed by Framasoft) is "the free and decentralized alternative to video platforms, providing you over 400,000 videos published by 60,000 users and viewed over 15 million times," according to its web site. But now they're exploring livestreaming, writes Debian developer Phil Hands (Slashdot reader #2,365): Holding DebConf20 online this year highlighted the effort involved in setting up Live Streaming using Free Software — something that is beyond the reach of many smaller events which is where PeerTube with Live Streaming should be a perfect fit. In June PeerTube had posted a roadmap with a humble request for donations in lieu of a crowdfunding campaign: At a time when no one knows what the future holds, we deem it inappropriate to start a crowdfunding campaign and threaten not to do our best on PeerTube if we don't get the necessary funds. We believe in the public utility of PeerTube, so much so that we commit to working on it for six months to make this v3 happen, even if we must do it with our own funds (which we had already done for v2). We still hope that by sharing this roadmap as widely as possible, some of you will support us in our approach with a donation that will allow us to fund this project. And this week PeerTube's official Twitter feed announced that "Thanks to Debian's €10,000 donation we've just reached the 4th step of our PeerTube fundraising" — livestreaming. "Many thanks to all those who donated. And it's not too late to contribute." "We hope this unconventional gesture from the Debian project will help us make this year somewhat less terrible," added the Debian blog, "and give us, and thus humanity, better Free Software tooling to approach the future." It describes their donation as "a strong sign of recognition from an international project — one of the pillars of the Free Software world — towards a small French association which offers tools to liberate users from the clutches of the web's giant monopolies." And secondly, "it's a substantial amount of help in these difficult times, supporting the development of a tool which equally belongs to and is useful to everyone. The strength of Debian's gesture proves, once again, that solidarity, mutual aid and collaboration are values which allow our communities to create tools to help us strive towards Utopia."

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A couple of hours later, the thread is still peaceful. Thankfully. My friend from the past refers to Trump as a businessman, which causes me to write this screed, which I did not add to the thread. I was curious to know, how does this businessman see the retired people packed into his audience, no distancing, no masks. Are they his customers? His team? His employees? Competitors? Serfs? Prisoners? Slaves? What kind of animal do you treat the way Trump is treating these people? To Trump are they even people?

I wanted to send an MP3 of the Trailblazers podcast about podcasting, but couldn't easily find it, and then realized I'd better download a copy and upload it to my server, because who knows how easy it'll be to find in a year or more. The web is pretty ephemeral.

"Facebook Inc. is demanding that a New York University research project cease collecting data about its political-ad targeting practices," reports the Wall Street Journal, "setting up a fight with academics seeking to study the platform without the company's permission." The dispute involves the NYU Ad Observatory, a project launched last month by the university's engineering school that has recruited more than 6,500 volunteers to use a specially designed browser extension to collect data about the political ads Facebook shows them. In a letter sent October 16 to the researchers behind the NYU Ad Observatory, Facebook said the project violates provisions in its terms of service that prohibit bulk data collection from its site. "Scraping tools, no matter how well-intentioned, are not a permissible means of collecting information from us," said the letter, written by a Facebook privacy policy official, Allison Hendrix. If the university doesn't end the project and delete the data it has collected, she wrote, "you may be subject to additional enforcement action...." Facebook said it already offers more transparency into political advertising than either traditional media or rival social platforms, and that the automated collection of data from users' on-platform activity — even with their permission — poses an unacceptable privacy threat... What limitations on social media data scraping are enforceable has been the subject of litigation in recent years, with platforms arguing they have both a right and responsibility to prevent the unauthorized use of user-generated data. The NYU project has already collected the targeting data behind more than 200,000 ads. Researchers say it has exposed areas where the publicly available archive of political ads Facebook created after the 2016 election is failing to log advertisements that should be in the system. Facebook said it has appreciated the NYU researchers' efforts to improve the ad library, but won't stand for violations of its rules. Laura Edelson, a researcher at NYU's Tandon School of Engineering who helps oversee the Ad Observatory project, said, "The only thing that would prompt us to stop doing this would be if Facebook would do it themselves, which we have called on them to do...." The article also includes a reaction from the associate director of Georgetown's Institute for Data, Democracy, and Politics. "There's far too much critical information closed up behind Facebook's walled garden. And efforts like the Ad Observatory play a critical role in breaking down those walls."

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Don't want to jinx things, but when Biden takes office I assume the FBI will fully investigate what really happened in the 2016 election, without any interference from political appointees. The new Attorney General releases the reports Barr wouldn't let us see. I assume that's going to happen too.

What if we determine that the election was a crime. That the Trump campaign didn't just collude with Russia, it was Russia. Recent revelations about Manafort say that pretty clearly. Everyone was looking for collusion, but it was actually much worse.

We were an occupied country for four years. Should we allow anything Trump did in those four years to stand? Or do we just remove the three Supreme Court justices he nominated, tear up all his executive orders, remove all the regulations passed by his agencies. Undo anything that can be reasonably undone.

I don't think i's fair to the USA to make us live with the results of a totally invalid election.

We may be, right now, as sure as we're ever going to be that Trump was removed by the people in the 2020 vote.

I posted a very short question on Facebook. Do you know anyone like Trump? I asked because I do. I grew up in Queens, a couple of miles from where Trump grew up, only ten years after. So there were lots of Trump-like people in my area. I'm constantly reminded, by something Trump does, of someone I knew in childhood. Anyway, after a dozen or so predictable responses, a former Apple exec, one who did a very good thing for my troubled company back in 1986, said yes he's had golfed with Trump, voted for him in 2016, and was going to vote for him in 2020. He lives in California, so his vote is symbolic, as is mine (I live in NY). It was jarring. No debate has followed, thankfully, and I hope it doesn't. I'm just going to leave it there. I probably will add a link to this post to the comment thread.

I realized Trump has killed a lot more Americans than Osama bin Laden.

Early voting starts in New York State today.