aarondubrow writes: Finding new drugs that can more effectively kill cancer cells or disrupt the growth of tumors is one way to improve survival rates for ailing patients. Researchers are using supercomputers at the Texas Advanced Computing Center to find new chemotherapy drugs and to test known compounds to determine if they can fight different types of cancer. Recent efforts have yielded promising drug candidates, potential plant-derived compounds and new target sites that can lead to more effective drugs. From the Texas Advanced Computing Center: "Identifying a new drug by intuition or trial and error is expensive and time consuming. Virtual screening, on the other hand, uses computer simulations to explore how a large number of small molecule compounds 'dock,' or bind, to a target to determine if they may be candidates for future drugs. [...] In September 2016, writing in the journal Oncogene, Rommie Amaro, professor of Chemistry and Biochemistry at the University of California, reported results from the largest atomic-level simulation of the tumor suppression protein [p53] to date -- comprising more than 1.5 million atoms. The simulations helped to identify new 'pockets' -- binding sites on the surface of the protein -- where it may be possible to insert a small molecule that could reactivate p53. They revealed a level of complexity that is very difficult, if not impossible, to experimentally test. According to Amaro, computing provides a better understanding of cancer mechanisms and ways to develop possible novel therapeutic avenues."

Read more of this story at Slashdot.

aarondubrow writes: Finding new drugs that can more effectively kill cancer cells or disrupt the growth of tumors is one way to improve survival rates for ailing patients. Researchers are using supercomputers at the Texas Advanced Computing Center to find new chemotherapy drugs and to test known compounds to determine if they can fight different types of cancer. Recent efforts have yielded promising drug candidates, potential plant-derived compounds and new target sites that can lead to more effective drugs. From the Texas Advanced Computing Center: "Identifying a new drug by intuition or trial and error is expensive and time consuming. Virtual screening, on the other hand, uses computer simulations to explore how a large number of small molecule compounds 'dock,' or bind, to a target to determine if they may be candidates for future drugs. [...] In September 2016, writing in the journal Oncogene, Rommie Amaro, professor of Chemistry and Biochemistry at the University of California, reported results from the largest atomic-level simulation of the tumor suppression protein [p53] to date -- comprising more than 1.5 million atoms. The simulations helped to identify new 'pockets' -- binding sites on the surface of the protein -- where it may be possible to insert a small molecule that could reactivate p53. They revealed a level of complexity that is very difficult, if not impossible, to experimentally test. According to Amaro, computing provides a better understanding of cancer mechanisms and ways to develop possible novel therapeutic avenues."

Read more of this story at Slashdot.

Authorities detain accused drug trafficker who launched power bid after arrest of Sinaloa cartel leader Joaquin Guzman.

Columnist Ben Bajarin, writing for TechPinions: The big story is customer satisfaction with AirPods is extremely high. 98% of AirPod owners said they were very satisfied or satisfied. Remarkably, 82% said they were very satisfied. The overall customer satisfaction level of 98% sets the record for the highest level of satisfaction for a new product from Apple. When the iPhone came out in 2007, it held a 92% customer satisfaction level, iPad in 2010 had 92%, and Apple Watch in 2015 had 97%. Bajarin notes that the site surveyed 942 AirPods customers.

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An anonymous reader quotes a report from Business Insider: In San Francisco, where robots already run food deliveries for Yelp's Eat24 and make lattes at a mall coffee kiosk, one politician is working to ensure the city stays ahead of the curve. Supervisor Jane Kim is exploring a tax on robots as one solution to offset the economic devastation a robot-powered workforce might bring. Companies that use robots to perform tasks previously done by humans would pay the city. Those public funds might be used to help retrain workers who lose their jobs to robots or to finance a basic income initiative. Kim, one of 11 city supervisors in San Francisco, has been interviewing tech leaders, labor groups, and public policy experts in the hopes of creating a task force that will explore how a "robot tax" might be implemented. San Francisco would become the first city to create such a tax, after European lawmakers rejected a similar proposal in February. Kim learned the concept of a robot tax when Bill Gates called for one in an interview with Quartz. It struck a chord with the San Francisco politician, who represents some of the poorest and wealthiest residents across the Tenderloin, South of Market, Civic Center, Treasure Island, and several other neighborhoods. She hears of robots cropping up in hotels, hospitals, and even her local bar, and worries about how automation might deepen the income gap.

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Troops' vehicle attacked by gunmen after hitting a mine, in latest assault in area regularly targeted by armed groups.

Troops' vehicle attacked by gunmen after hitting a mine, in latest assault in area regularly targeted by armed groups.

Egypt's former vice president says he is having a difficult time renewing his passport.

Egypt's former vice president says he is having a difficult time renewing his passport.